Several epidemiological studies have reported a relationship between maternal cigarette smoking and SIDS.
Of the various risk factors for SIDS, maternal smoking is one of the most predictive. Decreased ventilatory response to hypoxia is thought to be part of the pathophysiology of SIDS. Recent studies in neonatal lambs have shown that nicotine attenuated the ventilatory response to hypoxia21 and have led to the speculation that SIDS is related to the effects of nicotine on the central control of breathing.
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